منابع مشابه
Prevention of meningococcal disease.
Invasive disease caused by Neisseria meningitidis has an average annual incidence of one case per 100,000 in the United States. The disease can be rapidly fatal or result in severe neurologic and vascular sequelae despite antibiotic therapy. Antibiotic chemoprophylaxis with rifampin, ciprofloxacin, or ceftriaxone is required for household and other close contacts. Although the majority of cases...
متن کاملMeningococcal disease: changes in epidemiology and prevention
The human bacterial pathogen Neisseria meningitidis remains a serious worldwide health threat, but progress is being made toward the control of meningococcal infections. This review summarizes current knowledge of the global epidemiology and the pathophysiology of meningococcal disease, as well as recent advances in prevention by new vaccines. Meningococcal disease patterns and incidence can va...
متن کاملUnveiling New Aspects of Meningococcal Carriage and Disease Prevention.
Recently, two protein-based vaccines have been approved for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB). It is therefore important to study carefully if and how these pathogens respond to widespread vaccination. Traditionally, meningococci have been classified on the basis of capsular phenotypes, but variable levels of capsule expression ...
متن کاملVaccine prevention of meningococcal disease: making slow progress.
All is not well in the fight against menin-gococcal disease. Despite the availability, for decades, of meningococcal vaccines, Neisseria meningitidis remains a leading cause of meningitis, sepsis, and other serious infections in both industrialized nations and the developing world [1]. The meningitis belt in sub-Saharan Africa continues to suffer from devastating epidemics of infection due to s...
متن کاملRecent Progress in the Prevention of Serogroup B Meningococcal Disease
The widespread use of meningococcal polysaccharide conjugate vaccines has highlighted the challenge of providing protection against serogroup B disease. Over a period of 4 decades, vaccine development has focused on subcapsular protein antigens, first with outer membrane vesicle (OMV) vaccines against epidemic outbreaks, and more recently on new multicomponent vaccines designed to offer better ...
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ژورنال
عنوان ژورنال: Reviews in Medical Microbiology
سال: 1998
ISSN: 0954-139X
DOI: 10.1097/00013542-199801000-00004